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HbA 1c among 4918 patients with acute coronary syndrome randomized to ranolazine or placebo in the MERLIN-TIMI 36 trial.

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Additional research is needed to elucidate the mechanisms underlying the regulation of myocardial substrate metabolism by NO.

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Effects of metoprolol vs verapamil in patients with stable angina pectoris.

Long-acting nifedipine is especially well-tested in hypertensive anginal patients when added to β-blockade.

In this situation, conventional anti-ischaemic drugs, such as beta-blockers, nitrates, and calcium channel inhibitors, all work on the factors leading to increased oxygen demand (i.

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To study whether ranolazine-induced microvascular recruitment is associated with increased muscle delivery of insulin, we used 125I-insulin to trace native insulin movement in vivo to determine muscle insulin uptake.

In certain cases, electrocardiographic stress testing is of borderline help, particularly in the presence of an abnormal resting electrocardiogram.

Ranolazine at therapeutic levels can inhibit the cardiac late sodium current (l Na).

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The characteristics of discomfort-related to myocardial ischaemia (angina pectoris) may be divided into four categories: location, character, duration and relationship to exertion and other exacerbating or relieving factors.

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Hg increase in mean diastolic blood pressure was observed in 6 patients with severe renal insufficiency on ranolazine 500 mg twice daily.

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After oral administration of 14C-ranolazine as a solution, 73% of the dose is systemically available as ranolazine or metabolites.

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Resumption of COUMADIN administration reverses the effect of vitamin K, and a therapeutic INR can again be obtained by careful dosage adjustment.

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Specifically, when low doses of either agent were given alone, there was no protective effect, but the drug combination prevented the ischaemia-induced fall in AF threshold, reduced AF inducibility, and shortened AF duration while decreasing T-wave heterogeneity, a clinically relevant measure of susceptibility to life-threatening ventricular arrhythmias.

In patients with high blood levels of cholesterol, the first medical intervention is lifestyle changes, especially a low-fat diet and increased exercise (see below).

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Report finds that new-generation computed tomography (NGCCT) may be sufficiently accurate to diagnose clinically significant coronary artery disease (CAD) in some, or all, difficult-to-image patient groups and may be particularly useful in ruling out patients from further invasive investigations.

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Ranolazine is a unique anti-ischaemic drug that does not significantly affect haemodynamic parameters such as heart rate and blood pressure.

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Further support for this concept comes from studies in pigs with ischemic heart failure induced by chronic coronary artery constriction, where there is no myocardial lactate production during intense β-adrenergic stimulation despite a chronic reduction in contractile function and MV̇ o 2 at rest ().

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Of note, among patients without CSA prior to their acute event, no such significant treatment effects were reported.

The bioavailability of oral ranolazine relative to that from a solution is 76%.

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Serious drug interactions can occur when certain medicines are used together with ranolazine.

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We hypothesized that ranolazine would be safe and well tolerated and would improve symptoms, exercise capacity, and parameters of RV structure and function.

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Inhibition of the rapidly activating delayed rectifier potassium current ( IKr) by ranolazine explains the effect of the drug to prolong ventricular and atrial action potential duration, as well as the small QTc interval prolongation observed in clinical trials.

Angiotensin-converting enzyme (ACE) inhibitors, such as ramipril (Altace), are antihypertensive drugs that can reduce the likelihood of acute ischemic episodes, strokes, and death in patients with CAD (Humphreys, 2011; Mayo Clinic, 2013b).

Ranolazine at therapeutic levels can inhibit the cardiac late sodium current (INa).

For many patients, adjusting to the lifestyle changes needed to manage CAD can take time.

E-4031 (60 nM) and dronedarone (6 μM); F: E-4031 (60 nM) and dronedarone (10 μM); G: E-4031 (60 nM), dronedarone (10 μM), and ranolazine (6-10 μM).

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In this context, ranolazine has consistently demonstrated its anti-ischaemic properties and has been shown to prolong exercise duration, and time to occurrence of ischaemia, without significantly affecting haemodynamic parameters such as heart rate or blood pressure.

The antianginal properties of the drug are due to inhibition of the late inward sodium current.

The therapeutic effect of ranolazine on exercise duration was no longer evident within 2 days after therapy was withdrawn.

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The subcellular compartmentation of fatty acid transporters is regulated differently by insulin and by AICAR.

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