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In the breast cancer prevention studies, the overall risk of these blood clots over 5 years of treatment was less than 1%.

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Second, in both patients with primary cancer and those with metastatic disease, resistance occurs as early as 12 to 18 months after the initiation of tamoxifen therapy.

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Alternatively, women may feel that surgical sterilization, either through tubal ligation or partner vasectomy, is their only highly effective option.

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This report is based on the results presented to the data and safety monitoring committee on August 22, 2003; it includes data on efficacy through August 19, 2003, and data on adverse events through February 28, 2003.

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Refer to the section in the section of this summary for a discussion of OC use and breast cancer in this population.

Our results demonstrated that tamoxifen treatment significantly accelerated Twist1 protein degradation in multiple cell types, including HEK293 kidney epithelial cells with ectopically expressed Twist1 and 4T1 and 168FARN mammary tumor cells with endogenously expressed Twist1.

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Anderson Cancer Center at Houston and at Yale University School of Medicine discovered that breast cancer patients who develop uterine cancer while using tamoxifen are likely to have a fast-moving, lethal form of the disease.

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American Society of Clinical Oncology 2003 update on the role of bisphosphonates and bone health issues in women with breast cancer.

Tamoxifen is a pharmaceutical anti-estrogen that directly competes with estrogen at the level of the receptor and is commonly used for the treamtent of breast cancer.

Most of my patients, like Jill (not her real photo) do not know that they are taking it.

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Noncompliance may explain a few cases of apparent drug resistance.

Early stage papillary and follicular thyroid cancer is treated by surgery to remove all or part of the thyroid, followed by hormone therapy and, in some cases, radioactive iodine.

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Let's hope that won't be for another 5 or so years!

If a parent has not the authority to decide how or what their own child is treated, is the State or are medical institutions essentially laying claim to owning that child's body?

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Large relative risk measures do not mean that there will be large effects in the actual number of individuals at a population level because the disease outcome may be quite rare.

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However, study limitations included pooling of populations without subgroup analysis, using a mix of population-based and hospital-based controls, and basing results on unadjusted estimates (as cases and controls were matched on only a few common factors); therefore, results should be interpreted in the context of these limitations.

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Clinically detected" is defined as detected by imaging studies (excluding lymphoscintigraphy) or by clinical examination and having characteristics highly suspicious for malignancy or a presumed pathologic macrometastasis based on fine-needle aspiration biopsy with cytologic examination.

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Population: This recommendation applies to asymptomatic women aged 35 years or older without a prior diagnosis of breast cancer, ductal carcinoma in situ, or lobular carcinoma in situ.

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Data based on 154 families with loss-of-function PALB2 mutations suggest that this gene may be an important cause of hereditary breast cancer, with risks that overlap with BRCA2.

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Decisions about the type and duration of adjuvant hormone therapy must be made on an individual basis.

However, a subgroup of patients who were using a levonorgestrel-IUD at the time of diagnosis and who continued using it, experienced an increased risk of breast cancer recurrence.

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