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When cyclophosphamide is administered intravenously, the usual dose is 40 to 50 mg per kg body weight in divided doses over a period of 2 to 5 days every 2-4 weeks or 10 to 15 mg per kg body weight every 7 to 10 days or 3 to 5 mg per kg body weight twice weekly.

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This is not to be confused with uricemia, or hyperuricemia, a build up of uric acid what store sales in the blood.

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In addition, three patients had undergone prior HSCT within the year preceding study entry.

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Patients were treated within a Finnish Medicines Agency FIMEA regulated Advanced Therapy Access Program (ISRCTN10141600) according to Good Clinical Practice and the Declaration of Helsinki.

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Although no therapy is proved to reverse the vascular and fibrotic damage in patients with scleroderma, several therapies are available in an effort to slow down disease progression, improve vascular function, limit mortality, and provide supportive symptomatic care.

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The combination of cyclophosphamide, thalidomide and dexamethasone is an effective alternative to cyclophosphamide - vincristine -doxorubicin - methylprednisolone as induction chemotherapy prior to autologous transplantation for multiple myeloma: a case-matched analysis.

Treatment of retinoblastoma as part of a combination regimen.

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Nonetheless, although there is greater acknowledgment of these risks, there remain few data on the long-term benefits and risks of treating membranous lupus nephritis with potent immunosuppressants ().

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Since 2000, Mary Krane Derr has written freelance for publications ranging from the medical journal "Allergy and Clinical Immunology International" to "The Polish American Encyclopedia.

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Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat).

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Outcomes after matched unrelated donor versus identical sibling hematopoietic cell transplantation in adults with acute myelogenous leukemia.

In this context, the risks of trastuzumab will necessitate great caution in its use, especially when it is combined with an anthracycline.

Cyclophosphamide is biotransformed principally in the liver to active alkylating metabolites by a mixed function microsomal oxidase system.

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Do not receive a "live" vaccine while using cyclophosphamide, and avoid coming into contact with anyone who has recently received a live vaccine.

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To date, the most useful piece of literature on this subject was published in 2011 in the Journal of Hematology Oncology Pharmacy.

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Mucosa-associated lymphoid tissue lymphomas (MALT) usually involve the gastrointestinal tract, thyroid, lungs, saliva glands, or skin.

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The primary analysis of PFS will be performed including all randomized eligible patients using a one-sided log-rank test stratified on IPI (2-3 vs.

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It is eliminated primarily in the form of metabolites, but from 5% to 25% of the dose is excreted in urine as unchanged drug.

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The amelioration of oxidative stress with astaxanthin pre-treatment correlated well with the decreased DNA damage as evident from normal and modified alkaline comet assays of bone marrow cells and peripheral blood lymphocytes.

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However, even with treatment, 10 to 30 percent of people with lupus nephritis develop kidney failure, described as end-stage renal disease when treated with blood-filtering treatments called dialysis or a kidney transplant.

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But in animal studies, pregnant animals were given this medication, and the babies did not show any medical issues related to this medication.

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Administration of cyclophosphamide to pregnant mice, rats, rabbits and monkeys during the period of organogenesis at doses at or below the dose in patients based on body surface area resulted in various malformations, which included neural tube defects, limb and digit defects and other skeletal anomalies, cleft lip and palate, and reduced skeletal ossification.

Stable disease (SD) was defined as when there was no evident change from the pre-treatment condition.

As would be expected with these inflammatory patterns of injury, patients usually benefit from immunosuppression.

Since the ANCA response was not associated with the primary end point, it is possible that the clinical efficacies of both rituximab and cyclophosphamide are due to mechanisms beyond autoantibody suppression.

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Osteosarcoma: intra-arterial treatment of the primary tumor with cis-diammine-dichloroplatinum II (CDP).

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Laboratories isolating PBMCs had to pass a documented qualification procedure, including the successful performance of test runs.

Patients who undergo radiation or who are on long-term steroid therapy have an increased risk for cataracts.

Cytoreductive Surgery and Intraperitoneal Hyperthermic Chemotherapy for Peritoneal Surface Malignancy: Non-Colorectal Indications.

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